XB-IMG-132415
Xenbase Image ID: 132415
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FIG. 3. Alignment of the amino acid
sequence of XlP2Y with P2Y1–7. The
alignment was made using CLUSTAL W;
only sequences between the highly conserved
NH2-terminal cysteine and the
end of TM VII were included in the analysis
(amino acid numbers are indicated at
the end of the alignment). Proteins
aligned to XlP2Y are chick P2Y1
(X73268), human P2Y2 (U07225), chick
p2y3 (X98283), human P2Y4 (X91852),
chick p2y5 (L06109), human P2Y6
(X97058), and human P2Y7 (U41070).
Gaps (-) were introduced to maximize the
alignment, and only non-conserved residues
are indicated for P2Y1–7. The 26 absolutely
conserved amino acids are indicated
(*), as are the four positively
charged amino acids reported to play a
role in P2Y2 receptor activation by ATP
and UTP (@) and the seven putative
transmembrane domains (bars) of XlP2Y.
Note the highly conserved sequence in
TM III (SILFLTCIS) and the strong homology
between XlP2Y and the UTP receptors
P2Y2 and P2Y4 in TM VII
(YKVTRPLASANSC(I/L)DP(I/V)LY). Image published in: Bogdanov YD et al. (1997) Copyright © 1997. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View |