FIG. 3. Alignment of the amino acid sequence of XlP2Y with P2Y1–7. The alignment was made using CLUSTAL W; only sequences between the highly conserved NH2-terminal cysteine and the end of TM VII were included in the analysis (amino acid numbers are indicated at the end of the alignment). Proteins aligned to XlP2Y are chick P2Y1 (X73268), human P2Y2 (U07225), chick p2y3 (X98283), human P2Y4 (X91852), chick p2y5 (L06109), human P2Y6 (X97058), and human P2Y7 (U41070). Gaps (-) were introduced to maximize the alignment, and only non-conserved residues are indicated for P2Y1–7. The 26 absolutely conserved amino acids are indicated (*), as are the four positively charged amino acids reported to play a role in P2Y2 receptor activation by ATP and UTP (@) and the seven putative transmembrane domains (bars) of XlP2Y. Note the highly conserved sequence in TM III (SILFLTCIS) and the strong homology between XlP2Y and the UTP receptors P2Y2 and P2Y4 in TM VII (YKVTRPLASANSC(I/L)DP(I/V)LY).
Image published in: Bogdanov YD et al. (1997)
Copyright © 1997. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.
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