XB-IMG-135562
Xenbase Image ID: 135562
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Fig. 4. RARγ2 knockdown alters expression of posterior Hox and PSM markers. (A-J′) Embryos were injected unilaterally at the 2- or 4-cell stage with 7.5 ng Rarγ2.1 MO+7.5 ng Rarγ2.2 MO. Injected side is indicated by magenta β-gal lineage tracer. Rarγ2.1/2.2 MO decreases expression of (A) Hoxc10 (18/18 embryos), (B) Hoxd10 (12/12), (C) Hoxa11 (9/9) and (D) Hoxc13 (16/16) in tailbud stage embryos. Rarγ2.1/2.2 MO decreases lateral, but expands midline, expression (green lines) of (E) Msgn1 (10/13) and (F) Tbx6 (8/11), knocking down and shifting expression rostrally of (G) Thyl2 (13/15) and (H) Ripply2 (13/14) in tailbud stage embryos. Rarγ2.1/2.2 MO decreases lateral, but expands midline, expression (green lines) of (I) Msgn1 (35/36) and (J) Tbx6 (20/20) in neurula stage embryos. Embryos shown in dorsal view with anterior on left. (I′,J′) Caudal views of I and J. Image published in: Janesick A et al. (2014) Copyright © 2014. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View |