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XB-IMG-150098

Xenbase Image ID: 150098


Fig. 1. BMP pathway activity in the developing Xenopus epidermis. (A) Immunostaining of cryosectioned Xenopus embryos revealed that the pSmad1/5/8 signal (red) colocalises with nuclear DAPI staining (blue) in both inner and outer layer cells. (B) (Left) In embryos injected with linearised plasmid DNA for the MCC reporter α-tub::GFP (50 pg/embryo), the pSmad1/5/8 signal (red) colocalised with GFP immunostaining (green). (Middle) In embryos injected with linearised plasmid DNA for the ionocyte reporter pendrin::GFP (25 pg/ embryo), the pSmad1/5/8 signal (red) colocalised with GFP immunostaining (green). (Right) The pSmad1/5/8 signal (red) colocalised with P63 protein expression (white). For each marker and stage, a representative cell (yellow arrowhead) is displayed at higher magnification to show the double staining. The white dashed and dotted lines respectively mark the apical surface of the ectodermal outer layer and the boundary between the outer and the inner ectodermal layers.

Image published in: Cibois M et al. (2015)

Copyright © 2015. Image reproduced on Xenbase with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.

GeneCloneSynonymsSpeciesStage(s)Tissue
smad1.L Xsmad1, smad-1, Xmad1, MLP, XMad, smad1-a, smad1-bX.laevisThroughout NF stage 9presumptive ectoderm
nucleus
smad1.L Xsmad1, smad-1, Xmad1, MLP, XMad, smad1-a, smad1-bX.laevisThroughout NF stage 10ectoderm
ectodermal cell
nucleus
smad1.L Xsmad1, smad-1, Xmad1, MLP, XMad, smad1-a, smad1-bX.laevisThroughout NF stage 12non-neural ectoderm
nucleus
ectoderm
ectodermal cell
smad1.L Xsmad1, smad-1, Xmad1, MLP, XMad, smad1-a, smad1-bX.laevisThroughout NF stage 15non-neural ectoderm
nucleus
ectoderm
ectodermal cell
epidermis
smad1.L Xsmad1, smad-1, Xmad1, MLP, XMad, smad1-a, smad1-bX.laevisThroughout NF stage 19non-neural ectoderm
ectoderm
ectodermal cell
nucleus
epidermis
smad9.L xsmad9, smad8, smad8a, smad8bX.laevisThroughout NF stage 9presumptive ectoderm
nucleus
smad9.L xsmad9, smad8, smad8a, smad8bX.laevisThroughout NF stage 10ectoderm
ectodermal cell
nucleus
smad9.L xsmad9, smad8, smad8a, smad8bX.laevisThroughout NF stage 12ectoderm
ectodermal cell
non-neural ectoderm
nucleus
smad9.L xsmad9, smad8, smad8a, smad8bX.laevisThroughout NF stage 15ectoderm
ectodermal cell
non-neural ectoderm
nucleus
epidermis
smad9.L xsmad9, smad8, smad8a, smad8bX.laevisThroughout NF stage 19ectoderm
ectodermal cell
non-neural ectoderm
nucleus
epidermis
smad1.L Xsmad1, smad-1, Xmad1, MLP, XMad, smad1-a, smad1-bX.laevisThroughout NF stage 12ectoderm
ectodermal cell
non-neural ectoderm
multiciliated cell
epithelium
epithelial cell
smad1.L Xsmad1, smad-1, Xmad1, MLP, XMad, smad1-a, smad1-bX.laevisThroughout NF stage 15epidermis
epidermal cell
epithelium
epithelial cell
non-neural ectoderm
ectoderm
ectodermal cell
multiciliated cell
mucociliary epithelium
smad1.L Xsmad1, smad-1, Xmad1, MLP, XMad, smad1-a, smad1-bX.laevisThroughout NF stage 17ectoderm
ectodermal cell
non-neural ectoderm
epidermis
epidermal cell
epithelium
epithelial cell
multiciliated cell
mucociliary epithelium
ciliated epidermal cell
smad1.L Xsmad1, smad-1, Xmad1, MLP, XMad, smad1-a, smad1-bX.laevisThroughout NF stage 19ectoderm
ectodermal cell
non-neural ectoderm
epidermis
epidermal cell
epithelium
epithelial cell
multiciliated cell
mucociliary epithelium
ciliated epidermal cell
smad1.L Xsmad1, smad-1, Xmad1, MLP, XMad, smad1-a, smad1-bX.laevisThroughout NF stage 25ectoderm
epidermis
ectodermal cell
non-neural ectoderm
ciliated epidermal cell
epidermal cell
epithelium
epidermis outer layer
epithelial cell
multiciliated cell
mucociliary epithelium
smad1.L Xsmad1, smad-1, Xmad1, MLP, XMad, smad1-a, smad1-bX.laevisThroughout NF stage 32ectoderm
epidermis
ectodermal cell
epidermis outer layer
epidermal cell
epithelium
epithelial cell
multiciliated cell
mucociliary epithelium
ciliated epidermal cell
smad9.L xsmad9, smad8, smad8a, smad8bX.laevisThroughout NF stage 12ectoderm
ectodermal cell
non-neural ectoderm
multiciliated cell
epithelium
epithelial cell
ciliated cell
smad9.L xsmad9, smad8, smad8a, smad8bX.laevisThroughout NF stage 15epidermis
mucociliary epithelium
epidermal cell
epithelium
epithelial cell
non-neural ectoderm
ectoderm
ectodermal cell
multiciliated cell
ciliated epidermal cell
smad9.L xsmad9, smad8, smad8a, smad8bX.laevisThroughout NF stage 17ectoderm
epidermis
ectodermal cell
non-neural ectoderm
epidermal cell
ciliated epidermal cell
multiciliated cell
mucociliary epithelium
epithelium
epithelial cell
smad9.L xsmad9, smad8, smad8a, smad8bX.laevisThroughout NF stage 19ectoderm
epidermis
ectodermal cell
non-neural ectoderm
epidermal cell
ciliated epidermal cell
epithelium
epithelial cell
mucociliary epithelium
multiciliated cell
smad9.L xsmad9, smad8, smad8a, smad8bX.laevisThroughout NF stage 25ectoderm
epidermis
ectodermal cell
non-neural ectoderm
ciliated epidermal cell
epidermal cell
epithelium
epithelial cell
mucociliary epithelium
multiciliated cell
epidermis outer layer
smad9.L xsmad9, smad8, smad8a, smad8bX.laevisThroughout NF stage 32ectoderm
epidermis
ectodermal cell
epidermis outer layer
mucociliary epithelium
epidermal cell
epithelium
multiciliated cell
ciliated epidermal cell
epithelial cell
smad1.L Xsmad1, smad-1, Xmad1, MLP, XMad, smad1-a, smad1-bX.laevisThroughout NF stage 15ectoderm
epidermis
ectodermal cell
ionocyte
epithelium
epithelial cell
mucociliary epithelium
non-neural ectoderm
smad1.L Xsmad1, smad-1, Xmad1, MLP, XMad, smad1-a, smad1-bX.laevisThroughout NF stage 17ectoderm
epidermis
ectodermal cell
non-neural ectoderm
ionocyte
epithelium
mucociliary epithelium
smad1.L Xsmad1, smad-1, Xmad1, MLP, XMad, smad1-a, smad1-bX.laevisThroughout NF stage 19ectoderm
epidermis
ectodermal cell
non-neural ectoderm
mucociliary epithelium
epidermal cell
ionocyte
epithelium
epithelial cell
smad1.L Xsmad1, smad-1, Xmad1, MLP, XMad, smad1-a, smad1-bX.laevisThroughout NF stage 25ectoderm
epidermis
ectodermal cell
non-neural ectoderm
epidermis outer layer
mucociliary epithelium
epidermal cell
epithelium
epithelial cell
ionocyte
smad1.L Xsmad1, smad-1, Xmad1, MLP, XMad, smad1-a, smad1-bX.laevisThroughout NF stage 32ectoderm
epidermis
neuroectoderm
ectodermal cell
epidermis outer layer
mucociliary epithelium
epidermal cell
epithelium
epithelial cell
ionocyte
smad9.L xsmad9, smad8, smad8a, smad8bX.laevisThroughout NF stage 15ectoderm
epidermis
ectodermal cell
non-neural ectoderm
mucociliary epithelium
epidermal cell
epithelium
epithelial cell
ionocyte
smad9.L xsmad9, smad8, smad8a, smad8bX.laevisThroughout NF stage 17ectoderm
epidermis
ectodermal cell
non-neural ectoderm
mucociliary epithelium
epidermal cell
epithelium
epithelial cell
ionocyte
smad9.L xsmad9, smad8, smad8a, smad8bX.laevisThroughout NF stage 19ectoderm
epidermis
ectodermal cell
non-neural ectoderm
mucociliary epithelium
epidermal cell
epithelium
epithelial cell
ionocyte
smad9.L xsmad9, smad8, smad8a, smad8bX.laevisThroughout NF stage 25ectoderm
epidermis
non-neural ectoderm
epidermis outer layer
epidermal cell
epithelium
epithelial cell
ionocyte
smad9.L xsmad9, smad8, smad8a, smad8bX.laevisThroughout NF stage 32ectoderm
epidermis
ectodermal cell
epidermis outer layer
mucociliary epithelium
epidermal cell
epithelium
ionocyte
smad1.L Xsmad1, smad-1, Xmad1, MLP, XMad, smad1-a, smad1-bX.laevisThroughout NF stage 15ectoderm
epidermis
ectodermal cell
non-neural ectoderm
epidermal cell
epithelium
epithelial cell
smad1.L Xsmad1, smad-1, Xmad1, MLP, XMad, smad1-a, smad1-bX.laevisThroughout NF stage 17ectoderm
epidermis
ectodermal cell
non-neural ectoderm
epidermal cell
epithelium
epithelial cell
smad1.L Xsmad1, smad-1, Xmad1, MLP, XMad, smad1-a, smad1-bX.laevisThroughout NF stage 25ectoderm
epidermis
ectodermal cell
non-neural ectoderm
epidermis inner layer
epidermal cell
smad1.L Xsmad1, smad-1, Xmad1, MLP, XMad, smad1-a, smad1-bX.laevisThroughout NF stage 32ectoderm
epidermis
ectodermal cell
epidermis inner layer
epidermal cell
epithelium
epithelial cell
smad9.L xsmad9, smad8, smad8a, smad8bX.laevisThroughout NF stage 15ectoderm
epidermis
ectodermal cell
non-neural ectoderm
epidermal cell
epithelium
epithelial cell
smad9.L xsmad9, smad8, smad8a, smad8bX.laevisThroughout NF stage 17ectoderm
epidermis
ectodermal cell
non-neural ectoderm
epidermal cell
epithelium
epithelial cell
smad9.L xsmad9, smad8, smad8a, smad8bX.laevisThroughout NF stage 25ectoderm
epidermis
ectodermal cell
non-neural ectoderm
epidermis inner layer
epidermal cell
epithelium
epithelial cell
smad9.L xsmad9, smad8, smad8a, smad8bX.laevisThroughout NF stage 32ectoderm
epidermis
ectodermal cell
epidermis inner layer
epidermal cell
epithelium
epithelial cell
tp63.L trp63, ket, tp73l, Xp63, p63, np63X.laevisThroughout NF stage 15ectoderm
epidermis
ectodermal cell
non-neural ectoderm
epidermal cell
epithelium
epithelial cell
tp63.L trp63, ket, tp73l, Xp63, p63, np63X.laevisThroughout NF stage 17ectoderm
epidermis
ectodermal cell
non-neural ectoderm
epidermal cell
epithelium
epithelial cell
tp63.L trp63, ket, tp73l, Xp63, p63, np63X.laevisThroughout NF stage 25ectoderm
epidermis
ectodermal cell
non-neural ectoderm
epidermis inner layer
epidermal cell
epithelium
epithelial cell
tp63.L trp63, ket, tp73l, Xp63, p63, np63X.laevisThroughout NF stage 32ectoderm
epidermis
ectodermal cell
epidermis inner layer
epidermal cell
epithelium
epithelial cell

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