Fig. 1. BMP pathway activity in the developing Xenopus epidermis. (A) Immunostaining of cryosectioned Xenopus embryos revealed that the pSmad1/5/8 signal (red) colocalises with nuclear DAPI staining (blue) in both inner and outer layer cells. (B) (Left) In embryos injected with linearised plasmid DNA for the MCC reporter α-tub::GFP (50 pg/embryo), the pSmad1/5/8 signal (red) colocalised with GFP immunostaining (green). (Middle) In embryos injected with linearised plasmid DNA for the ionocyte reporter pendrin::GFP (25 pg/ embryo), the pSmad1/5/8 signal (red) colocalised with GFP immunostaining (green). (Right) The pSmad1/5/8 signal (red) colocalised with P63 protein expression (white). For each marker and stage, a representative cell (yellow arrowhead) is displayed at higher magnification to show the double staining. The white dashed and dotted lines respectively mark the apical surface of the ectodermal outer layer and the boundary between the outer and the inner ectodermal layers.
Image published in: Cibois M et al. (2015)
Copyright © 2015. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| smad1.L | MLP, smad-1, smad1-a, smad1-b, XMad, Xmad1, Xsmad1 | X. laevis | Throughout NF stage 9 | presumptive ectoderm nucleus |
| smad1.L | MLP, smad-1, smad1-a, smad1-b, XMad, Xmad1, Xsmad1 | X. laevis | Throughout NF stage 10 | ectoderm ectodermal cell nucleus |
| smad1.L | MLP, smad-1, smad1-a, smad1-b, XMad, Xmad1, Xsmad1 | X. laevis | Throughout NF stage 12 | non-neural ectoderm nucleus ectoderm ectodermal cell |
| smad1.L | MLP, smad-1, smad1-a, smad1-b, XMad, Xmad1, Xsmad1 | X. laevis | Throughout NF stage 15 | non-neural ectoderm nucleus ectoderm ectodermal cell epidermis |
| smad1.L | MLP, smad-1, smad1-a, smad1-b, XMad, Xmad1, Xsmad1 | X. laevis | Throughout NF stage 19 | non-neural ectoderm ectoderm ectodermal cell nucleus epidermis |
| smad9.L | smad8, smad8a, smad8b, xsmad9 | X. laevis | Throughout NF stage 9 | presumptive ectoderm nucleus |
| smad9.L | smad8, smad8a, smad8b, xsmad9 | X. laevis | Throughout NF stage 10 | ectoderm ectodermal cell nucleus |
| smad9.L | smad8, smad8a, smad8b, xsmad9 | X. laevis | Throughout NF stage 12 | ectoderm ectodermal cell non-neural ectoderm nucleus |
| smad9.L | smad8, smad8a, smad8b, xsmad9 | X. laevis | Throughout NF stage 15 | ectoderm ectodermal cell non-neural ectoderm nucleus epidermis |
| smad9.L | smad8, smad8a, smad8b, xsmad9 | X. laevis | Throughout NF stage 19 | ectoderm ectodermal cell non-neural ectoderm nucleus epidermis |
| smad1.L | MLP, smad-1, smad1-a, smad1-b, XMad, Xmad1, Xsmad1 | X. laevis | Throughout NF stage 12 | ectoderm ectodermal cell non-neural ectoderm multiciliated cell epithelium epithelial cell |
| smad1.L | MLP, smad-1, smad1-a, smad1-b, XMad, Xmad1, Xsmad1 | X. laevis | Throughout NF stage 15 | epidermis epidermal cell epithelium epithelial cell non-neural ectoderm ectoderm ectodermal cell multiciliated cell mucociliary epithelium |
| smad1.L | MLP, smad-1, smad1-a, smad1-b, XMad, Xmad1, Xsmad1 | X. laevis | Throughout NF stage 17 | ectoderm ectodermal cell non-neural ectoderm epidermis epidermal cell epithelium epithelial cell multiciliated cell mucociliary epithelium ciliated epidermal cell |
| smad1.L | MLP, smad-1, smad1-a, smad1-b, XMad, Xmad1, Xsmad1 | X. laevis | Throughout NF stage 19 | ectoderm ectodermal cell non-neural ectoderm epidermis epidermal cell epithelium epithelial cell multiciliated cell mucociliary epithelium ciliated epidermal cell |
| smad1.L | MLP, smad-1, smad1-a, smad1-b, XMad, Xmad1, Xsmad1 | X. laevis | Throughout NF stage 25 | ectoderm epidermis ectodermal cell non-neural ectoderm ciliated epidermal cell epidermal cell epithelium epidermis outer layer epithelial cell multiciliated cell mucociliary epithelium |
| smad1.L | MLP, smad-1, smad1-a, smad1-b, XMad, Xmad1, Xsmad1 | X. laevis | Throughout NF stage 32 | ectoderm epidermis ectodermal cell epidermis outer layer epidermal cell epithelium epithelial cell multiciliated cell mucociliary epithelium ciliated epidermal cell |
| smad9.L | smad8, smad8a, smad8b, xsmad9 | X. laevis | Throughout NF stage 12 | ectoderm ectodermal cell non-neural ectoderm multiciliated cell epithelium epithelial cell ciliated cell |
| smad9.L | smad8, smad8a, smad8b, xsmad9 | X. laevis | Throughout NF stage 15 | epidermis mucociliary epithelium epidermal cell epithelium epithelial cell non-neural ectoderm ectoderm ectodermal cell multiciliated cell ciliated epidermal cell |
| smad9.L | smad8, smad8a, smad8b, xsmad9 | X. laevis | Throughout NF stage 17 | ectoderm epidermis ectodermal cell non-neural ectoderm epidermal cell ciliated epidermal cell multiciliated cell mucociliary epithelium epithelium epithelial cell |
| smad9.L | smad8, smad8a, smad8b, xsmad9 | X. laevis | Throughout NF stage 19 | ectoderm epidermis ectodermal cell non-neural ectoderm epidermal cell ciliated epidermal cell epithelium epithelial cell mucociliary epithelium multiciliated cell |
| smad9.L | smad8, smad8a, smad8b, xsmad9 | X. laevis | Throughout NF stage 25 | ectoderm epidermis ectodermal cell non-neural ectoderm ciliated epidermal cell epidermal cell epithelium epithelial cell mucociliary epithelium multiciliated cell epidermis outer layer |
| smad9.L | smad8, smad8a, smad8b, xsmad9 | X. laevis | Throughout NF stage 32 | ectoderm epidermis ectodermal cell epidermis outer layer mucociliary epithelium epidermal cell epithelium multiciliated cell ciliated epidermal cell epithelial cell |
| smad1.L | MLP, smad-1, smad1-a, smad1-b, XMad, Xmad1, Xsmad1 | X. laevis | Throughout NF stage 15 | ectoderm epidermis ectodermal cell ionocyte epithelium epithelial cell mucociliary epithelium non-neural ectoderm |
| smad1.L | MLP, smad-1, smad1-a, smad1-b, XMad, Xmad1, Xsmad1 | X. laevis | Throughout NF stage 17 | ectoderm epidermis ectodermal cell non-neural ectoderm ionocyte epithelium mucociliary epithelium |
| smad1.L | MLP, smad-1, smad1-a, smad1-b, XMad, Xmad1, Xsmad1 | X. laevis | Throughout NF stage 19 | ectoderm epidermis ectodermal cell non-neural ectoderm mucociliary epithelium epidermal cell ionocyte epithelium epithelial cell |
| smad1.L | MLP, smad-1, smad1-a, smad1-b, XMad, Xmad1, Xsmad1 | X. laevis | Throughout NF stage 25 | ectoderm epidermis ectodermal cell non-neural ectoderm epidermis outer layer mucociliary epithelium epidermal cell epithelium epithelial cell ionocyte |
| smad1.L | MLP, smad-1, smad1-a, smad1-b, XMad, Xmad1, Xsmad1 | X. laevis | Throughout NF stage 32 | ectoderm epidermis neuroectoderm ectodermal cell epidermis outer layer mucociliary epithelium epidermal cell epithelium epithelial cell ionocyte |
| smad9.L | smad8, smad8a, smad8b, xsmad9 | X. laevis | Throughout NF stage 15 | ectoderm epidermis ectodermal cell non-neural ectoderm mucociliary epithelium epidermal cell epithelium epithelial cell ionocyte |
| smad9.L | smad8, smad8a, smad8b, xsmad9 | X. laevis | Throughout NF stage 17 | ectoderm epidermis ectodermal cell non-neural ectoderm mucociliary epithelium epidermal cell epithelium epithelial cell ionocyte |
| smad9.L | smad8, smad8a, smad8b, xsmad9 | X. laevis | Throughout NF stage 19 | ectoderm epidermis ectodermal cell non-neural ectoderm mucociliary epithelium epidermal cell epithelium epithelial cell ionocyte |
| smad9.L | smad8, smad8a, smad8b, xsmad9 | X. laevis | Throughout NF stage 25 | ectoderm epidermis non-neural ectoderm epidermis outer layer epidermal cell epithelium epithelial cell ionocyte |
| smad9.L | smad8, smad8a, smad8b, xsmad9 | X. laevis | Throughout NF stage 32 | ectoderm epidermis ectodermal cell epidermis outer layer mucociliary epithelium epidermal cell epithelium ionocyte |
| smad1.L | MLP, smad-1, smad1-a, smad1-b, XMad, Xmad1, Xsmad1 | X. laevis | Throughout NF stage 15 | ectoderm epidermis ectodermal cell non-neural ectoderm epidermal cell epithelium epithelial cell |
| smad1.L | MLP, smad-1, smad1-a, smad1-b, XMad, Xmad1, Xsmad1 | X. laevis | Throughout NF stage 17 | ectoderm epidermis ectodermal cell non-neural ectoderm epidermal cell epithelium epithelial cell |
| smad1.L | MLP, smad-1, smad1-a, smad1-b, XMad, Xmad1, Xsmad1 | X. laevis | Throughout NF stage 25 | ectoderm epidermis ectodermal cell non-neural ectoderm epidermis inner layer epidermal cell |
| smad1.L | MLP, smad-1, smad1-a, smad1-b, XMad, Xmad1, Xsmad1 | X. laevis | Throughout NF stage 32 | ectoderm epidermis ectodermal cell epidermis inner layer epidermal cell epithelium epithelial cell |
| smad9.L | smad8, smad8a, smad8b, xsmad9 | X. laevis | Throughout NF stage 15 | ectoderm epidermis ectodermal cell non-neural ectoderm epidermal cell epithelium epithelial cell |
| smad9.L | smad8, smad8a, smad8b, xsmad9 | X. laevis | Throughout NF stage 17 | ectoderm epidermis ectodermal cell non-neural ectoderm epidermal cell epithelium epithelial cell |
| smad9.L | smad8, smad8a, smad8b, xsmad9 | X. laevis | Throughout NF stage 25 | ectoderm epidermis ectodermal cell non-neural ectoderm epidermis inner layer epidermal cell epithelium epithelial cell |
| smad9.L | smad8, smad8a, smad8b, xsmad9 | X. laevis | Throughout NF stage 32 | ectoderm epidermis ectodermal cell epidermis inner layer epidermal cell epithelium epithelial cell |
| tp63.L | ket, np63, p63, tp73l, trp63, Xp63 | X. laevis | Throughout NF stage 15 | ectoderm epidermis ectodermal cell non-neural ectoderm epidermal cell epithelium epithelial cell |
| tp63.L | ket, np63, p63, tp73l, trp63, Xp63 | X. laevis | Throughout NF stage 17 | ectoderm epidermis ectodermal cell non-neural ectoderm epidermal cell epithelium epithelial cell |
| tp63.L | ket, np63, p63, tp73l, trp63, Xp63 | X. laevis | Throughout NF stage 25 | ectoderm epidermis ectodermal cell non-neural ectoderm epidermis inner layer epidermal cell epithelium epithelial cell |
| tp63.L | ket, np63, p63, tp73l, trp63, Xp63 | X. laevis | Throughout NF stage 32 | ectoderm epidermis ectodermal cell epidermis inner layer epidermal cell epithelium epithelial cell |
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