XB-IMG-150101
Xenbase Image ID: 150101
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Fig. 4. BMP pathway overactivation
affects the formation of MCCs and
mucus-producing cells in HAEC
cultures. (A,A′) Chronic treatment of HAEC
cultures with 100 ng/ml BMP2 drastically
decreased the numbers of both MUC5ACpositive
goblet cells and acetylated tubulinpositive
MCCs relative to untreated
controls. DAPI was added to confirm the
presence of cells (A′). (B) Quantification of
the experiments illustrated in A,A′
performed in triplicate; data show mean±
s.d. from three donors; ***P<0.001,
**P<0.01, Student’s t-test. (C) HAECs
chronically exposed to 100 ng/ml BMP2
upregulated the squamous metaplasia
markers involucrin (IVL) and
transglutaminase 1 (TGM1). CTR, control;
UBC, ubiquitin C. Image published in: Cibois M et al. (2015) Copyright © 2015. Image reproduced with permission of the Publisher. Larger Image Printer Friendly View |