Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Xenbase Image ID: 150101

Fig. 4. BMP pathway overactivation affects the formation of MCCs and mucus-producing cells in HAEC cultures. (A,A′) Chronic treatment of HAEC cultures with 100 ng/ml BMP2 drastically decreased the numbers of both MUC5ACpositive goblet cells and acetylated tubulinpositive MCCs relative to untreated controls. DAPI was added to confirm the presence of cells (A′). (B) Quantification of the experiments illustrated in A,A′ performed in triplicate; data show mean± s.d. from three donors; ***P<0.001, **P<0.01, Student’s t-test. (C) HAECs chronically exposed to 100 ng/ml BMP2 upregulated the squamous metaplasia markers involucrin (IVL) and transglutaminase 1 (TGM1). CTR, control; UBC, ubiquitin C.

Image published in: Cibois M et al. (2015)

Copyright © 2015. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.

Larger Image
Printer Friendly View

Return to previous page
Xenbase: The Xenopus laevis and X. tropicalis resource.
Version: 4.11.3

Major funding for Xenbase is provided by grant P41 HD064556