XB-IMG-154071
Xenbase Image ID: 154071
Fig. 7.
Model of the proposed mechanism by which Tbx2 inhibits FGF signaling to regulate anterior neural formation. Tbx2 acts as a target gene of BMP signal to suppress the expression of Flrt3. Flrt3 potentiates FGF signaling (dashed arrow) and FGF signals can induce Flrt3 expression, creating a positive feedback loop. On the other hand, FGF signals inhibit BMP signaling by inducing the phosphorylation of Smad1 in its linker region (dashed line). Thus, it appears that the BMP/Tbx2 and FGF/Flrt3 pathways antagonize each other for the correct patterning of anterior neural tissues. Image published in: Cho GS et al. (2017) Copyright © 2017. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View |