Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Xenbase Image ID: 154071

Fig. 7. Model of the proposed mechanism by which Tbx2 inhibits FGF signaling to regulate anterior neural formation. Tbx2 acts as a target gene of BMP signal to suppress the expression of Flrt3. Flrt3 potentiates FGF signaling (dashed arrow) and FGF signals can induce Flrt3 expression, creating a positive feedback loop. On the other hand, FGF signals inhibit BMP signaling by inducing the phosphorylation of Smad1 in its linker region (dashed line). Thus, it appears that the BMP/Tbx2 and FGF/Flrt3 pathways antagonize each other for the correct patterning of anterior neural tissues.

Image published in: Cho GS et al. (2017)

Copyright © 2017. Image reproduced with permission of the Publisher, Elsevier B. V.

Larger Image
Printer Friendly View

Return to previous page
Xenbase: The Xenopus laevis and X. tropicalis resource.
Version: 4.12.3

Major funding for Xenbase is provided by grant P41 HD064556