Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-IMG-49214

Xenbase Image ID: 49214


Figure 6. Expression of RA-modifying genes during hindlimb regeneration. Dark blue stain indicates expression, white arrowheads mark the level of amputation; tissue to the right of this is regrowth. A–C:Cyp26b is expressed strongly in mesenchymal blastema cells, but is absent from the AEC. D–F:Crabp2 is also strongly upregulated in the blastema although it appears absent from the distal tip (white arrow in E). D′–F′: Expression of Crabp2 in non-regenerating, transgenic N1 tadpole hindlimbs to show residual expression. G–I:Raldh2 is not expressed in regenerating tissue but note that it is expressed in the anterior stump tissue (marked with a white asterisk) providing a potential source of RA to the blastema. Limbs are viewed from the dorsal side and oriented with proximal to the left and posterior uppermost, the tadpole's head is to the left. Scale bar in I = 0.5 mm (applies to all panels).

Image published in: McEwan J et al. (2011)

Copyright © 2011. Image reproduced with permission of the Publisher, John Wiley & Sons.

GeneSynonymsSpeciesStage(s)Tissue
cyp26b1.LX.laevisSometime during NF stage 52 to NF stage 56distal mesenchyme
regenerating tissue
blastema
wound epidermis
crabp2.LxCRABPX.laevisSometime during NF stage 52 to NF stage 56distal mesenchyme
blastema
mesenchyme
regenerating tissue
anterior
posterior
aldh1a2.Lraldh2, XRaldh2, raldh-2X.laevisSometime during NF stage 52 to NF stage 56blastema
mesenchyme
anterior
wound epidermis

Image source: Published

Larger Image
Printer Friendly View

Quality:
Good quality Poor quality
comment [+]
Return to previous page
Xenbase: The Xenopus Model Organism Knowledgebase.
Version: 4.14.0
Major funding for Xenbase is provided by grant P41 HD064556