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XB-IMG-77882

Xenbase Image ID: 77882


Fig. 5. Osr1/Osr2 act upstream of Wnt-mediated pulmonary specification and RA-regulated lung bud growth. (A-G) Osr1/Osr2-MO- and MM-MO-injected embryos were treated at stages 25-35 with DMSO vehicle, 10 μM BIO or 1 μM all-trans-retinoic acid (RA), and analyzed for nkx2.1, sox2, wnt2b and raldh2 at stage 35 (A-F) and sftpc at stage 42 (dorsal view) (G). Black arrows indicate normal expression, red arrows show absent expression, green arrows and lines indicate expanded expression and white arrows indicate rescued expression.

Image published in: Rankin SA et al. (2012)

Copyright © 2012. Image reproduced on Xenbase with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.

GeneCloneSynonymsSpeciesStage(s)Tissue
nkx2-1.L ttf1, nkx2.1, titf1, Xnkx-2.1, xnkx2-1X.laevisSometime during NF stage 32 to NF stage 35 and 36endoderm
foregut
lung primordium
brain
forebrain
head
pharyngeal arch
eye
thyroid primordium
sox2.S XLSOX-2, Sox-2, XSox2, Xsox-2, anop3, mcops3X.laevisSometime during NF stage 32 to NF stage 33 and 34foregut
brain
spinal cord
head region
pharyngeal arch
otic vesicle
endoderm
wnt2b.L Xwnt-2b, xwnt2b, wnt-2b, wnt2b-a, wnt2b-bX.laevisThroughout NF stage 33 and 34lateral plate mesoderm
lens placode
pineal gland
otic vesicle
pharyngeal arch
aldh1a2.L raldh2, XRaldh2, raldh-2X.laevisSometime during NF stage 33 and 34 to NF stage 35 and 36lens
otic vesicle
pronephric kidney
pronephric duct
adenohypophyseal placode
brain
midbrain
hindbrain
sftpc.S SP-C, xSP-C, SPC, surfcX.laevisThroughout NF stage 42lung
lung primordium

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