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Xenbase Image ID: 81667

Figure 1. Differential effects of Ngn3-GR temporal activation. Whole mount in situ hybridization of Stage 44 whole guts from embryos injected with 1,800 pg of XenopusNgn3-GR mRNA at the eight-cell stage. (a,d,g) Control embryos injected with Ngn3-GR mRNA but not treated with dex. (b,e,h) Dex treatment from Stages 12 to 44. Increased expression of glucagon (n = 14/20), insulin (n = 23/23), and somatostatin (n = 10/10). Arrowheads indicate ectopic insulin expression in the liver, stomach, and duodenum. (c,f,i) Dex treatment for 4 h from Stages 12 to 15. Increased insulin (n = 55/55) and somatostatin (n = 22/22) but not glucagon (n = 24/24). (j,k) Schematics illustrating organs in the whole gut of panels a and b (blue-insulin). (l) Insulin expression was detected in rare instances (n = 2/50) in posterior areas of the intestine. Pa: pancreas.

Image published in: Oropeza D and Horb M (2012)

Copyright © 2012. Image reproduced with permission of the Publisher, John Wiley & Sons.

ins.Spreproinsulin, insulin I, ins1, xins, insulin, ins-b, ins-aX.laevisThroughout NF stage 44endoderm
sst.1.Ssom, somatostatin, smstX.laevisThroughout NF stage 44stomach
alimentary system
gcg.Lproglucagon I, glucagonX.laevisThroughout NF stage 44foregut

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