Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-IMG-84637

Xenbase Image ID: 84637


Figure 2. Establishment of the HSC Program and Arterial Specification of the DA Is Abolished in Tel1-Depleted Embryos (A) In situ hybridization analysis showing that expression of hematopoietic genes in the ventral wall of the DA (arrows) is absent in Tel1 morphants. In contrast, expression in embryonic erythrocytes (Runx1, Scl, and Lmo2, arrowheads) and myeloid cells (SpiB and Gfi1, arrowheads) is still observed. (B) Expression analysis showing that the DA (arrows) of Tel1 morphants does not express the arterial affiliated genes, Notch4, Dll4, and EphrinB2, nor the Notch target, Gata2. (C) Endothelial expression of Erg1 reveals the presence of DA precursors (arrows) coalescing in the midline of Tel1 morphants. All embryos were hybridized as whole mounts and are shown in lateral view, with anterior to the left and dorsal to the top. Stages of development are as indicated. The numbers of embryos represented by each panel, out of the number analyzed, are indicated in the top right corner. See also Figure S1 and Table S1.

Image published in: Ciau-Uitz A et al. (2010)

Copyright © 2010. Image reproduced on Xenbase with permission of the Publisher, Elsevier B. V.

GeneCloneSynonymsSpeciesStage(s)Tissue
runx1.L Xaml, aml1 oncogene, aml-1, Runx-1, aml1, aml, cbfa2, evi-1, amlcr1, pebp2ab, aml1-evi-1, Xaml1X.laevisSometime during NF stage 41 to NF stage 43dorsal aorta
ventral
tal1.L SCL, tal-1, bHLHa17, tcl5, stem cell leukaemia, xsclX.laevisSometime during NF stage 41 to NF stage 43dorsal aorta
ventral blood island
ventral
blood
hematopoietic stem cell
lmo2.L LMO-2, xlmo2, xlmo-2X.laevisSometime during NF stage 41 to NF stage 43dorsal aorta
ventral
runx1.L Xaml, aml1 oncogene, aml-1, Runx-1, aml1, aml, cbfa2, evi-1, amlcr1, pebp2ab, aml1-evi-1, Xaml1X.laevisSometime during NF stage 41 to NF stage 43blood

Image source: Published

Larger Image
Printer Friendly View

Quality:
Good quality Poor quality
comment [+]
Return to previous page
Xenbase: The Xenopus laevis and X. tropicalis resource.
Version: 4.9.0
Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556