Fig. 1. The activation of CPE-mediated cytoplasmic polyadenylation. In immature oocytes, CPE containing mRNAs already contain all the proteins necessary for polyadenylation as well as the deadenylase PARN. During oocyte maturation, phosphorylation of CPEB causes a rearrangement of the complex that leads to the ejection of PARN and the activation of the poly(A) polymerase Gld-2. 4E: eIF4E, 4A: eIF4A. For further description of this process, see the text.
Image published in: Radford HE et al. (2008)
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