Figure 7. Hipk1 knock-down and Xdd1 over-expression synergize to perturb gastrulation.(A) Reduction of Hipk1 levels by morpholino, or interference with Dsh function by expression of a dominant negative protein (Xdd1), each produce no gastrulation defects at low doses, with only mild neural tube closure defects (b, c vs. control a). Combining these low-dose treatments produces gastrulation defects plus more severe neural tube closure defects (d, e). (B) Gastrulation defects are present in 68% of embryos in the Xdd1+Hipk1MO group, but not at all in groups injected with either Xdd1 RNA or Hipk1MO alone.
Image published in: Louie SH et al. (2009)
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