Figure 2. Vangl1gt/gt homozygous embryos fail to turn.Vangl1+/gt heterozygous embryos are normal and they develop into viable, fertile adults. In contrast, ∼14% of Vangl1gt/gt mutants die at E9.5–10.5. (A', B') Cranial (A') and dorsal (B') views of Vangl1gt/gt mutant embryos shown in A and B showing open neural tube defects. (B, B') One mutant and its heterozygous littermate were stained for VANGL1-βGEO fusion protein. Each of five phenotypically mutant Vangl1gt/gt homozygotes isolated at this stage failed to turn from lordotic to fetal position.
Image published in: Antic D et al. (2010)
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