Figure 5. Actions of L-TBA on field responses at the CA1 Schaffer collateral-pyramidal neuron synapse.(A) Representative field EPSPs elicited in response to three stimuli delivered at 20 Hz in stratum radiatum. 30 µM L-TBA (black trace) prolonged fEPSPs relative to control (gray trace) in an activity-dependent manner (p = 0.02). The TBA prolongation was inhibited by co-application of 50 µM DL-APV (2nd black trace). (B) Summary of effects on fEPSP time-integrals elicited by 1, 2 and 3 stimuli normalized to corresponding fEPSPs in control ACSF (*p<.05 paired t-test; n = 9 slices for one and two stimuli, n = 5 slices for three stimuli).
Image published in: Sun W et al. (2011)
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