FIG. 5. Spatial expression of neural-specific genes is unaffected in antisense a6 integrin-treated embryos. Controls and embryos with repressed a6 integrin expression were examined by in situ hybridization for several neural-selective transcripts: nrp1 (A–F), Xanf1 (G–L), and sybII (M–R). In uninjected, control embryos the expression of these transcripts was examined in embryos of neural plate (stage 13; A, G, and M), neurula (stage 25; B, H, and N) and tail-bud (stage 35; C, I, and O) stages. The expression of these genes was also examined in embryos injected with antisense a6 integrin constructs and that displayed severe perturbation of neurulation at sibling stages of neural plate (stage 15; D, J, and P), neurula (stage 25; E, K, and Q), and tail-bud (stage 35; F, L, and R) stages. Scale bar represents 200 mm.
Image published in: Lallier TE and DeSimone DW (2000)
Copyright © 2000. Image reproduced with permission of the Publisher, Elsevier B. V.
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| nrp1.L | A5 antigen, LOC108718763, neuropilin, neuropilin-1, np-1, npn-1, nrp, nrp-1, pNPG152 | X. laevis | Sometime during NF stage 13 to NF stage 35 and 36 | neural plate pre-chordal neural plate chordal neural plate optic field anterior neural fold |
| hesx1.S | anf2, hesx1-a, hesx1-b, rpx, Xanf, Xanf-1, XANF-2, Xanf1, Xanf2 | X. laevis | Sometime during NF stage 13 to NF stage 35 and 36 | anterior neural fold |
| vamp2.S | syb2, sybii, synaptobrevin 2, synaptobrevin2, vamp-2, vamp2-a, vamp2-b | X. laevis | Sometime during NF stage 13 to NF stage 35 and 36 | neural plate |
| nrp1.L | A5 antigen, LOC108718763, neuropilin, neuropilin-1, np-1, npn-1, nrp, nrp-1, pNPG152 | X. laevis | Throughout NF stage 25 | neural tube posterior neural tube anterior neural tube optic vesicle |
| nrp1.L | A5 antigen, LOC108718763, neuropilin, neuropilin-1, np-1, npn-1, nrp, nrp-1, pNPG152 | X. laevis | Throughout NF stage 35 and 36 | central nervous system brain spinal cord eye otic vesicle |
| hesx1.S | anf2, hesx1-a, hesx1-b, rpx, Xanf, Xanf-1, XANF-2, Xanf1, Xanf2 | X. laevis | Throughout NF stage 25 | |
| vamp2.S | syb2, sybii, synaptobrevin 2, synaptobrevin2, vamp-2, vamp2-a, vamp2-b | X. laevis | Throughout NF stage 25 | neural tube posterior neural tube anterior neural tube |
| vamp2.S | syb2, sybii, synaptobrevin 2, synaptobrevin2, vamp-2, vamp2-a, vamp2-b | X. laevis | Throughout NF stage 35 and 36 | central nervous system brain spinal cord eye cranial nerve |
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