Figure 9 Genetic cascades involved in the activation and autocatalytic regulation of BMP-4. While BMP-4 activatesXvent-2 and GATA-2, only Xvent-2 is able to up-regulate BMP-4. BMP-2 protein translated from maternal RNA activates Xvent-2 and triggers the autocatalytic loop, which is subsequently maintained by BMP-4 and Xvent-2 recruiting a yet unknown co-activator. Xvent-2 suppresses gsc. GATA-2 and Xvent-2 activate Xvent-1 which has been shown to repress ventral expression of the dorsal lip-specific winged helix geneXFD-1′ (12, 24, 31, 47).
Image published in: Schuler-Metz A et al. (2000)
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