Fig. 3. PSM markers are modulated by RARγ-selective agonist and inverse agonist. (A-R) WISH from embryos treated post-gastrulation (stage 12.5) with 10 nM 4647, 0.5 µM 5099 or vehicle (0.1% ethanol). (A-D) Control expression of Msgn1, Tbx6, Thyl2 and Ripply2. (E) Msgn1 expression diminished by 4647 treatment (17/17 embryos). (F) Tbx6 expression expanded by 4647 treatment (22/22). (G,H) Somitomere domains of Thyl2 (19/19) and Ripply2 (17/17) are thicker and posteriorly expanded. (I,J) Msgn1 (17/17) and Tbx6 (13/13) expression expanded by 5099 treatment. (K,L) Somitomere domains of Thyl2 (15/17) and Ripply2 (26/26) are fewer and thinner. Embryos are shown in dorsal view at neurula stage, anterior to left. (M-R) Caudal views of Msgn1 and Tbx6.
Image published in: Janesick A et al. (2014)
Copyright © 2014. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.
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