Figure 3. Effect of MPC088 on α1β3γ2 and α4β3δ GABAAR-expressing oocytesData in each group obtained from 4 oocytes. a: Aggregate concentration-response data (mean ± SD) obtained from α1β3γ2 (black) and α4β3δ (red) receptors with co-applied GABA at similar ~EC8 dose (i.e., 3 μM for the former and 0.05 μM for the latter receptor type) and varying concentrations of trans-dominant MPC088. Response amplitudes obtained from each oocyte normalized to its saturating GABA response (i.e., responses obtained with 1,000 μM GABA for α1β3γ2 and 100 μM GABA for α4β3δ GABAARs). b: Aggregate concentration-response data (mean ± SD) obtained from α1β3γ2 (black) and α4β3δ (red) receptors with trans-dominant MPC088 alone. Data similarly normalized to the saturating GABA response obtained from each oocyte. Results for α1β2γ2 GABAARs in a and b (blue) reproduced from those of Figures 1c and 2b, respectively.
Image published in: Yue L et al. (2012)
Image downloaded from an Open Access article in PubMed Central. Image reproduced on Xenbase with permission of the publisher and the copyright holder.
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