Figure 6. Reduced hind limb responsivity to TH in hind limb phenotype tadpoles. Normal and hind limb (HL) mutant phenotype tadpoles from the same clutch were treated with 0 or 10 nM T3 for 7 days. Hind limbs in mutant phenotype tadpoles (middle row) were compared with normal tadpoles of the same age (top row, age matched) or at the same stage (bottom row, stage matched). In the absence of T3, hind limbs advanced up to two stages in 7 days in normal and mutant phenotype tadpoles, (compare day 0-T3 and day 7-T3). In the presence of T3 (compare day 0-T3 and day 7+T3), hind limbs in normal tadpoles advanced from NF stage 48 to NF stage 51 (top row) or from NF stage 53 to NF stage 57 (bottom row), whereas hind limbs of mutant phenotype tadpoles advanced from NF stages 53 to NF stage 55. Importantly, the effect of T3 in mutant hind limbs (no difference in stage but slight increase in hind limb length) was greatly reduced compared with the effect in normal tadpoles of the same stage (compare day 7-T3 and day 7+T3). Hind limb images were photographed with the same magnification. This experiment was repeated with a sample size of four to six with similar results.
Image published in: Choi J et al. (2015)
Image reproduced on Xenbase with permission of the publisher and the copyright holder. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license
| Experiment + Assay | Source | Phenotypes and Disease | ||
|---|---|---|---|---|
| Xla Wt + thra TALEN + NF53 (morphology) | Fig 6. row 2 column 1 |
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| Xla Wt + thra TALEN + NF55 (morphology) | Fig 6. row 2 column 2 |
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