Fig. 11. General histologic features of aniridia-like mutant froglet eyes. Compared with wild-type eyes (A), these mutants show variable defects in cornea, iris, lens and retina. Most notably, the pupil diameter is much wider in the mutants (B and C). Lenses show variable reduction in size and differentiation consistent with the variable presence of cataracts visible upon gross inspection of eyes of intact animals. While the retina is usually present and grossly normal, it may contain folds and the ganglion cell layer (gcl) is somewhat sparse and irregular. The retina may be partially absent as shown in C. Scale bar in panel A=100 µm.
Image published in: Nakayama T et al. (2015)
Copyright © 2015. Image reproduced with permission of the Publisher, Elsevier B. V.
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