Fig 10. Rescue of pkdcc1Mo and pkdcc2Mo phenotype by JNK and dnJNK, respectively. (A- G) Four cell stage embryos were injected dorsally with coMo (A), pkdcc1Mo (B-D) or pkdcc2Mo (E-G) and incubated until blastopore closure. The pkdcc1Mo phenotype (delay in blastopore closure) was rescued by injection with JNK mRNA (C) but not with dominant negative JNK (dnJNK) mRNA(D). Contrary, pkdcc2Mo phenotype was rescued by the injection with the dnJNK mRNAbut not with JNK mRNA. (H-N) Four cell stage embryos were unilaterally injected with coMo (H), pkdcc1Mo (I-K) or pkdcc2Mo (L-N) and incubated until neural tube closure. Once again, the phenotype observed in the absence of Pkdcc1 (delay in neural tube closure) was rescued by the overexpression of JNK mRNA (J) but not of dnJNK mRNA (K). Contrary, pkdcc2Mo phenotype was rescued by co-injection of dnJNK mRNA (M) but not of JNK mRNA (N).
Image published in: Vitorino M et al. (2015)
Image reproduced on Xenbase with permission of the publisher and the copyright holder. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license
| Experiment + Assay | Source | Phenotypes and Disease | ||
|---|---|---|---|---|
| Xla Wt + pkdcc.1 MO + NF12 (morphology) | fig.10.b |
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| Xla Wt + pkdcc.2 MO + NF16 (morphology) | fig.10.e |
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| Xla Wt + pkdcc.1 MO + NF16 (morphology) | fig.10.i |
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| Xla Wt + pkdcc.2 MO + NF16 (morphology) | fig.10.l |
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