Fig. 8. The Dg adhesome is involved throughout notochord morphogenesis. The data have established that, when Dg binds to laminin, the RKKRK and PPEY sites of the cytoplasmic domain are mobilized to ensure cell polarity and mediolateral intercalation. Laminin-Dg interactions lead to phosphorylation of the tyrosine residue in the PPPYVPP site to generate a signaling pathway that allows vacuole differentiation. Finally, an adhesome comprising laminin-Dg-myosin-IIA-actin is established to maintain cortical integrity during vacuolation. The sheath is shown in yellow. (Adapted from Keller et al., 1989.)
Image published in: Buisson N et al. (2014)
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