Fig 5. Integrin α6 and VICKZ expression during CNC delamination.Cross-sections at the midbrain level from chick embryos at 5ss (A,D,G), 8ss (B,E,H), and 12ss (C,F,I) were double stained with antibodies against Integrin α6 (A-C) and VICKZ (D-F). Merged images are shown in panels G-I. Higher magnification of the regions indicated by rectangles in G-I are shown in G’-I’. Integrin α6 is co-expressed with VICKZ in the neural folds in 5ss embryos (G, arrows, G’), undergoes down-regulation concomitantly with VICKZ as CNC delaminate (H, arrows, H’), and remains down-regulated, as does VICKZ, immediately following CNC emigration (I, arrowhead, I’).
Image published in: Carmel MS et al. (2015)
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