Fig. 7. A model of the action of GATA4 in ectodermal explants. (A) GATA4 converts embryonic ectoderm to both endodermal and cardiomyocyte fates. Endoderm and WNT/β-catenin antagonise cardiac tissue formation. (B) The dominant-negative Sox17 construct and the WNT antagonist Dkk1 each promote cardiomyocyte fate at the expense of endodermal fate. Sox17βEnR could inhibit the endoderm-inducing activity and promote the cardiogenic activity of GATA4 directly (1), and/or prevent the maintenance of endoderm (2), and/or convert endoderm to cardiomyocytes (3). WNT/β-catenin could interfere with cardiogenesis either directly or indirectly by promoting endoderm formation (Lickert et al., 2002).
Image published in: Latinkić BV et al. (2003)
Copyright © 2003. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.
Permanent Image Page
Printer Friendly View
XB-IMG-148258