Figure 7. XHYLS-1 is required for apical targeting/anchoring of basal bodies. (A) Representative images of control embryos and embryos depleted of XHYLS-1, Polaris or IFT-52, stained with antibodies to acetylated tubulin and γ-tubulin to illustrate effect on basal body distribution. Images are x–y projections of deconvolved 3D data stacks. (B) x–z projection of 3D data stacks presented in A and Figure 6C. (C) Model for the role of HYLS-1 in cilia formation. HYLS-1 is recruited to the forming centriole by its association with SAS-4, and like SAS-4 is locked into the centriole during the assembly of centriolar microtubules. Incorporation of HYLS-1 confers on centrioles the capacity to initiate ciliogenesis. Bars, 10 μm.
Image published in: Dammermann A et al. (2009)
Copyright © 2009. Image reproduced on with permission of the Publisher, Cold Spring Harbor Laboratory Press. This is an Open Access article.
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| tubg1.L | gamma tubulin, gamma-tubulin, Xgam | X. laevis | Throughout NF stage 28 | ciliated epidermal cell basal body |
| tuba4b.L | alpha tubulin, alpha-tubulin, tuba4, tuba4a | X. laevis | Throughout NF stage 28 | ciliated epidermal cell |
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