Fig. 8. nop gene has a mutation in the hps6 gene. (A) Schematic representation of the X. tropicalis genome (v.9.0) containing the nop locus, showing the locations of critical SSLP markers to identify the nop locus. The red circled gene model denotes hps6 and the blue circled gene model denotes hps1. (B) Schematic representation of the BAC clone, ISB1-52K13, containing the hps6 gene. Wildtype and nop mutated sequence of the hps6 gene are shown below the BAC. The numbers are positions relative to the ORF start site as 1. The embryos show the phenotypes associated with BAC clone injection. The top embryo is an uninjected nop embryo; the middle embryo was rescued with a wildtype BAC injection; and the bottom embryo was not rescued when injected with a BAC containing the nop mutation.
Image published in: Nakayama T et al. (2017)
Copyright © 2017. Image reproduced with permission of the Publisher, Elsevier B. V.
| Experiment + Assay | Source | Phenotypes and Disease | ||||
|---|---|---|---|---|---|---|
| Xtr.hps6mGrngr + nop BAC + NF42 (whole-mount microscopy) | Fig. 8 B |
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