Fig. 8. JNK inhibition disrupts eye morphogenesis. (A-E) The morphology of the eye was analysed in wild-type embryos treated from stage 11 to 22 with DMSO or increasing concentrations of SP600125, a JNK inhibitor. Scale bar: 500 µm. (F) The eye size was quantified from the embryos (A-E) as described in the Materials and methods; Mann–Whitney test (P values, 0.25 μg ml-1=0.93; 0.5 μg ml-1=7.8*10−5; 1 μg ml-1=1.02*10−8; 2.5 μg ml-1=1.07*10−5). The numbers indicate the embryos analysed. Note, the embryos show reduced eye formation in a dose-dependent manner. NS, non significant; ***P<0.001.
Image published in: Vacca B et al. (2016)
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