Fig 8. Endoscopic ventricle biopsy procedure in adult frogs induces a fibrous scar with absence of heart regeneration. Endoscopic procedure in anesthetised frog allows “in situ” live visualisation of the operating field and collection ventricle tissue in the apical region using biopsy forceps. The resulting outcome for the frog heart is the induction of scar related gene expression during the first week post-amputation (SHORT TERM) and the establishment of a persistent fibrous scar, cardiac hypertrophy and sarcomere disorganisation at the amputation site, without the capacity for the cardiac tissue to regenerate, even after almost one year (LONG TERM)
Image published in: Marshall L et al. (2017)
© 2017 Marshall et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license
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