Figure 7. A schematic model showing the role of Usp7 in the maintenance of DNA methylation. During S-phase, Uhrf1 binds to hemi-methylated DNA and ubiquitylates histone H3. Ubiquitylation of histone H3 facilitates the recruitment of Dnmt1/Usp7 complex to DNA methylation sites. Usp7 then deubiquitylates ubiquitylated histone H3, promoting DNA methylation.
Image published in: Yamaguchi L et al. (2017)
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