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Figure 6. Planar cell polarity (PCP) pathway regulates actin dynamics via small guanosine triphosphatases (GTPases). Downstream pathways of the PCP pathway for cytoskeletal regulations. Activation of (a) actin polymerizing factor Daam1 by Rho, and (b) actin branching factor Arp3 by Rac. (c) Phosphorylation of myosin light chain (Myl) by Rho and Rock (Rho-Rock-Myl cascade). (d) Phosphorylation and activation of LIM-kinase (LIMK) controlling F-actin severing cofilin function by Rho and Rock. (e) A feedback loop of cofilin on PCP proteins. (f) A feedback loop of contractile forces of actomyosin on PCP proteins.

Image published in: Shindo A (2018)

Image downloaded from an Open Access article in PubMed Central. © 2017 The Authors

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