Fig. 5. Activation of non-canonical wnt signalling rescues fzd7 CRD induced cardia bifida. (A, Ai) Wild type control embryos showing normal tnnic expression in the heart. (B, Bi) fzd7 full length overexpression (500pg) injected into the dorsal blastomeres (DB) at the 4 cell stage show normal heart expression of tnnic despite suffering a severe extension movement defect. (C). Embryos injected with 500pg fzd7 CRD show cardia bifida phenotype, note that embryos have normal to mild convergent extension defects. (D). Rescue of the fzd7 CRD (250pg) cardia bifida phenotype with 250pg full length fzd7, embryos show normal morphology as well as tnnic expression. (F). Graph of fzd7 CRD cardia bifida phenotype rescue with fzd7 Full length. (E, Ei). Rescue of fzd7 CRD (500pg) cardia bifida phenotype with 1.25ng dishevelled1-Delta-N (Dvl1N) indicating that fzd7 is required for the non-canonical signalling in the heart. (G). Graph of fzd7 CRD cardia bifida phenotype rescue with dvl1N, (Gi) is the key for the cardia bifida phenotype scoring in (G). Magnification 20x.
Image published in: Abu-Elmagd M et al. (2017)
© 2017. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| tnni3.L | c-troponin, cardiac tropin T, cardiac troponin I, cTnI, ctnIc, cTNT, TIc, TnIc, tnnic, troponin-ic, XcTnI, XTnIc | X. laevis | Throughout NF stage 29 and 30 | heart |
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