Fig. 1. Spreading of an NCC explant on fibronectin. (A) Bright field images of an NCC cluster explanted at stage 16–18. (B) Upper panel: oblique view onto a confocal image stack 3D reconstruction of a stage NCC cluster displaying the central and peripheral regions (upper panel). Lower panel: a y,z-section of the same image stack visualizes progressive cell flattening of demi-detached leader cells at the cell sheet margin. (C) Traction force map depicting enhanced cell-substrate traction associated with leader cell emigration. The flexible acrylamide substrate has a stiffness of 870 kPa.
Image published in: Blaue C et al. (2018)
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