Fig. 2. Creating a new pancreas, the future of diabetestherapy. Many future diabetes therapies revolve around theidea of creating new pancreas cells. There are two majorways to do this. Transdifferentiation involves changinga differentiated cell type into b cells by turning on pancreatictranscription factors in non-b cells. The other method isguiding stem cells (either from adult or embryonic tissue) tobecome pancreatic b cells using combinations of growthfactors and chemicals. ES cells, embryonic stem cells; EGF,epidermal growth factor; LIF, leukemia inhibitory factor.
Image published in: Pearl EJ and Horb ME (2008)
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