Figure S4. Patterning of Large-scale ZGA is Explained by Cell Size, and Elevated Levels of Histones Correlates to A More Stringent Cell Size Threshold. Related to Figure 4. ( A, B, C). (A-B) Defined boundary decisions for models of ZGA based on a perfect sizer or positional activation. (A) Hypothetical sizer: based on activation in cells below 45 µm. (B) Hypothetical activation within only animal hemisphere (vegetal side inhibited). Cells from 8 embryos at C12.8-13.5 data points are bins of 25 µm and 250 cells by z-position. Black square, transcription inactive cells; red triangle, tran- scription active cells; green line, decision boundary for ZGA. (C) F1 scores from decision boundary fitting (top) and fitting errors (bottom). FP, false positive; FN, false negative.
Image published in: Chen H et al. (2019)
Copyright © 2019. Image reproduced with permission of the Publisher, Elsevier B. V.
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