Fig. S3 The R180G disease variant. A) Alignment of RPSA amino acid sequence across selected metazoan species. Note that R180 (red box) is conserved. B) Structural model of the R180 residue in WT human RPSA using PyMol. R180 in wild-type human RPSA is shown with its predicted polar contacts with D14 and E181 in RPSA. Orange dotted lines indicate polar contacts. C) Substitution of R180 with a glycine (R180G) is predicted to abolish these interactions, likely destabilizing the protein’s tertiary structure.
Image published in: Griffin JN et al. (2018)
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