Supplemental Figure 8 Knockdown of emc1 in Xenopus results in abnormal nAChR signal in tail neuromuscular junctions that can be rescued through exogenous introduction of human EMC1. Injection of wildtype EMC1 mRNA and to a lesser extent p.Gly471Arg (c.1411G>C) variant mRNA restores nAChR patterns of expression in emc1 depleted tail neuromuscular tissue while mRNA of other variants do not. Three replicates of 8 embryos were analyzed for each condition. Scale bar indicates 50 μm. Images of uninjected control and emc1 MO labeling of nAChR are from subregions of images shown in Figure 4C.
Image published in: Marquez J et al. (2020)
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