Figure 6. The canonical Wnt signaling activates the expression of XPAPC via nodal signaling. A-H: Embryos were collected at stage 9.5 and in situ hybridized with XPAPC probe. Embryos were viewed from the vegetal side, with dorsal side up. C-H: LacZ mRNA was injected as lineage tracer and microinjection controls. A: Enhancing the canonical Wnt signaling by LiCl treatment expanded the expression of XPAPC to the whole marginal zone. B: The enhancement was blocked by perturbing nodal signaling through SB-431542 treatment which followed LiCl treatment. C-E: Blocking canonical Wnt pathway through LefEnR injection inhibited the expression of XPAPC (C), activating nodal signaling through Xnr2 injection rescued the expression (D). F-H: Activating the canonical Wnt signaling through LefVP16 injection induced the expression of XPAPC at ventral side of embryos (F), SB-431542 treatment blocked the endogenous and ectopic expression of XPAPC (G).
Image published in: Lou X et al. (2008)
Copyright © 2008. Image reproduced with permission of the Publisher, John Wiley & Sons.
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| pcdh8 | papc, paraxial protocadherin, xpapc | Xenopus | Throughout NF stage 10.5 | upper blastopore lip |
Image source: Published
Permanent Image Page
Printer Friendly View
XB-IMG-2704