Fig. 2. muzak is encoded by myh6. WISH shows myh6 expression in wild type heart (A, black arrow) and jaw muscle (white arrow) is diminished in muz (B). (C, D) myh6.2 is expressed in jaw muscle (white arrow) but not heart (black arrow), and is unaffected by the mutation. (E) Schematic showing domain structure of wild type X. tropicalis myh6 and the truncated protein lacking the myosin coiled-coil tail encoded by the muz allele. (F) Western blot analysis does not detect sarcomeric MHC protein in extracts of muz heart; silver stained loading control below. (Movie S2 and G) myh6 morphant hearts do not beat and show strong depletion of sarcomeric MHC protein relative to control morpholino-injected tadpoles; silver stained loading control below.
Image published in: Abu-Daya A et al. (2009)
Image reproduced on Xenbase with permission of the publisher and the copyright holder. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| myh6 | aMHC, ck231, MHC, MHC-alpha, MHCa, MHCalpha, muz, muzak, XCMHC | X. tropicalis | Throughout NF stage 37 and 38 | heart jaw muscle |
| myh7 | cmd1s, cmh1, LOC108707020, LOC108714868, mpd1, myh6.2, myhcb, spmd, spmm | X. tropicalis | Throughout NF stage 37 and 38 | jaw muscle |
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