Fig. 4. Bicc1 is epistatic to Pkd2. (A-A′) Analysis of the expression of nbc-1 in the Xenopus late distal tubule at stage 39 by whole-mount in situ hybridization of uninjected control embryos, and embryos radially injected with xBicC-MO1+2 in the presence or absence of a single injection of 2 ng pkd2 mRNA. (B) Quantification of the expression of nbc-1 in the late distal tubule from the experiments shown in A-A′. Black, bilateral expression; white, no expression; gray, unilateral expression rescued by co-injected mRNA. The number of embryos analyzed is indicated. (C-D) Reciprocal experiments to those in A-B using Xenopus embryos injected with either Pkd2-MO alone or together with pkd2-myc or bicc1 mRNA. Co-injection with pkd2-myc rescued nbc-1 expression, whereas co-injection with bicc1 did not. (E) Flow diagram outlining the proposed mechanism of Bicc1 activity.
Image published in: Tran U et al. (2010)
Copyright © 2010. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| slc4a4 | hhNMC, hnbc1, nbc1, nbc2, nbce1, pNBC, slc4a5, XNBC1 | Xenopus | Throughout NF stage 39 | late distal tubule |
Image source: Published
Permanent Image Page
Printer Friendly View
XB-IMG-41582