Figure 3. X-Delta-2 role in the establishment of the identity of the forebrain. A prime -E prime : Embryos injected with X-Delta-2 morpholino (MO) in the left-hand side were analyzed for the expression of the forebrain marker Pax-6 (A prime ,B prime ), the telencephalon marker Emx-2 (C prime ,D prime ), and the ventral forebrain marker Nkx2.1 (E prime ). Pax-6 and Emx-2 were analyzed at stage 21 (A,A prime and C,C prime , respectively), and at stage 25 (B,B prime and D,D prime , respectively), whereas Nkx2.1 was only analyzed at stage 25 (E,E prime ). Noninjected (Nic) controls are shown for each marker (A-E). All embryos are shown from the anterior side with dorsal to the top. The arrow in B prime indicates the loss of Pax-6 expression in the olfactory placode. Dotted lines in E and E prime indicate the midline. Asterisk indicates the injected side.
Image published in: Peres JN and Durston AJ (2006)
Copyright © 2006. Image reproduced with permission of the Publisher, John Wiley & Sons.
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| pax6.L | an2, mgda, pax-6, pax6-a, pax6-b, wagr, XLPAX6, xpax6 | X. laevis | Sometime during NF stage 21 to NF stage 25 | forebrain hindbrain neural tube optic vesicle anterior neural tube |
| nkx2-1.L | nkx2.1, titf1, ttf1, Xnkx-2.1, xnkx2-1 | X. laevis | Throughout NF stage 25 | forebrain telencephalon ventral |
| emx2.L | emx-2, xemx2 | X. laevis | Throughout NF stage 25 | forebrain telencephalon |
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