Larger Image Fig. 5. Tbx6 regulates anterior mesodermal genes including Tbx1. MO-injected sides (*) are shown by Magenta-GAL staining. Myf-5 (A, B) and MyoD (C, D) expressions in stage 32 embryos injected with Tbx6 exint-MO. (E, F) Pcdh18 expression in stage 31 embryos injected with Tbx6 exint-MO. Tbx1 expression in stages 27 (G, H) and 14 (I) embryos injected with Tbx6 exint-MO. Images of MO-injected sides are flipped horizontally to facilitate comparison. Lateral view, anterior to the left (A–H), anterior view, dorsal to top (I). (J, K) Tbx6 (magenta) and Tbx1 (turquoise) expressions as revealed by double in situ hybridization. Stage 14, lateral view, anterior to the left (J), stage 16, dorso-anterior view (K). (L) PCNS (magenta) and Tbx1 (turquoise) expressions as revealed by double in situ hybridization. Stage 25, lateral view, anterior to the left. (M) A horizontal paraffin section (8 μm) at the position indicated in L. Image published in: Tazumi S et al. (2010) Copyright © 2010. Image reproduced with permission of the Publisher, Elsevier B. V.
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