Fig. 3. Molecular characterization of the primary and second heart fields. (A-U) Developmental expression of Nkx2.5, Tbx5 and Tbx20 at stages 25, 30, 33 and 35 as indicated. The horizontal lines indicate the predicted position of primary heart field (PHF) and second heart field (SHF). All three genes are detected in the PHF, whereas the SHF expresses both Nkx2.5 and Tbx20 but is negative for Tbx5 expression. At later stages, the developing outflow tract (OFT), a derivative of the SHF, remains Tbx5 negative. (A,C,E,G,I,K,M-U) Lateral views, anterior to right. (B,D,F,H,J,L) Ventral views, anterior to top. V, ventricle. Scale bars: 100 μm.
Image published in: Lee YH and Saint-Jeannet JP (2011)
Copyright © 2011. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| nkx2-5.L | AR2, csx, Nkx-2.5, nkx-2.5, nkx2-5-a, nkx2-5-b, nkx2.5, tinman, XNkx-2.5, XNkx2-5 | X. laevis | Throughout NF stage 25 | heart primary heart field secondary heart field anterior placodal area heart primordium cardiac mesoderm |
| nkx2-5.L | AR2, csx, Nkx-2.5, nkx-2.5, nkx2-5-a, nkx2-5-b, nkx2.5, tinman, XNkx-2.5, XNkx2-5 | X. laevis | Throughout NF stage 29 and 30 | primary heart field secondary heart field cardiac mesoderm myocardium |
| nkx2-5.L | AR2, csx, Nkx-2.5, nkx-2.5, nkx2-5-a, nkx2-5-b, nkx2.5, tinman, XNkx-2.5, XNkx2-5 | X. laevis | Throughout NF stage 33 and 34 | heart primary heart field secondary heart field myocardium |
| nkx2-5.L | AR2, csx, Nkx-2.5, nkx-2.5, nkx2-5-a, nkx2-5-b, nkx2.5, tinman, XNkx-2.5, XNkx2-5 | X. laevis | Throughout NF stage 35 and 36 | heart outflow tract cardiac ventricle |
| tbx5.S | tbx-5, tbx5-a, tbx5-b, xtbx-5, xtbx5 | X. laevis | Throughout NF stage 25 to NF stage 29 and 30 | myocardium heart primary heart field retina cardiac mesoderm heart primordium |
| tbx5.S | tbx-5, tbx5-a, tbx5-b, xtbx-5, xtbx5 | X. laevis | Throughout NF stage 33 and 34 to NF stage 35 and 36 | myocardium heart cardiac ventricle retina |
| tbx20.L | XTBX20 | X. laevis | Throughout NF stage 25 | heart primary heart field secondary heart field cement gland primordium heart primordium |
| tbx20.L | XTBX20 | X. laevis | Throughout NF stage 29 and 30 | myocardium cement gland primary heart field secondary heart field hindbrain cardiac mesoderm retina |
| tbx20.L | XTBX20 | X. laevis | Throughout NF stage 33 and 34 to NF stage 35 and 36 | myocardium cement gland heart outflow tract cardiac ventricle cardiac mesoderm hindbrain retina |
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