Figure 5. PIAS genes differentially regulate signals from various growth factors. A: PIAS induced the neural markers with different efficiency, but none induced the expression of the mesodermal marker muscle actin. B: PIAS inhibited mesodermal induction by activin. C: PIAS blocked mesoderm induction by BMP4 with different effectiveness. D: PIAS1 reduced marker induction by Wnt8, but the other PIAS genes were ineffective; and PIAS4 enhanced, rather than inhibited, induction of the direct targets of Wnt signaling. The doses of the RNAs used in the experiments were: 1 ng PIAS1, 0.5 ng PIAS2, 2 ng PIAS3, 1 ng PIAS4; 2 pg activin, 20 pg BMP4, and 100 pg Wnt8.Download figure to PowerPoint
Image published in: Burn B et al. (2011)
Copyright © 2011. Image reproduced with permission of the Publisher, John Wiley & Sons.
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