Fig. 3. Neural crest markers in embryos with modulated Dvl and Ror2 function. (A-H)Xenopus embryos were injected with the indicated Dvl (Dsh construct) RNAs (1 ng each) and processed for in situ hybridization as described in Fig. 1. Schematic representations of the Dvl mutant constructs are shown at the top. Dsh-delta-N activates Sox8 (A) and FoxD3 (B) but not Sox2 (C). Dsh-DEP+ slightly expands Sox2 (D) but inhibits Sox8 (E), FoxD3 (F), Pax3 (G) and AP2 (H). (I-L)The effects of Ror2 interference on NC marker expression. Ror2-delta-C and Ror2MO, but not wild-type Ror2, inhibit FoxD3 (I,K,L). MyoD is not affected by Ror2-delta-C (J). Arrows point to altered marker expression. Dorso-anterior view is shown.
Image published in: Ossipova O and Sokol SY (2011)
Copyright © 2011. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| sox8.L | X. laevis | Throughout NF stage 14 to NF stage 16 | neural crest | |
| foxd3.L | fkh6, foxd3-a, foxd3-b, XFD-6, xfoxd3 | X. laevis | Throughout NF stage 14 to NF stage 16 | neural crest |
| sox2.L | anop3, LOC108718087, mcops3, Sox-2, XLSOX-2, Xsox-2, XSox2 | X. laevis | Sometime during NF stage 14 to NF stage 16 | neural crest |
| pax3.S | cdhs, hup2, pax-3, pax3-a, pax3-b, Waardenburg syndrome 1, ws1, xpax3 | X. laevis | Sometime during NF stage 14 to NF stage 16 | neural crest |
| myod1.S | mf25, MyoD, myod1-a, myod1-b, myogenic factor 3, XMyoD, XtmyoD | X. laevis | Sometime during NF stage 14 to NF stage 16 | presumptive paraxial mesoderm |
| tfap2a.L | ap2, AP2a, AP2alpha, tfap2a-a, tfap2a-b, tfap2alpha, XAP-2, xap2 | X. laevis | Sometime during NF stage 14 to NF stage 16 | neural crest |
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