Figure 2. Ngn3-GR activation affects anterior gut markers at Stage 44. (a) Exocrine pancreatic markers PDI and elastase are slightly decreased (n = 16/16 and n = 14/15, respectively). (e,f) Stomach marker cathepsin E is significantly reduced (n = 14/14). (g,h) Liver and duodenum marker hex is slightly decreased (n = 7/7). Pancreas is outlined in panels (c) and (d).
Image published in: Oropeza D and Horb M (2012)
Copyright © 2012. Image reproduced with permission of the Publisher, John Wiley & Sons.
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| pdia2.L | pdi, pdip, XPDIp | X. laevis | Throughout NF stage 44 | foregut pancreas exocrine pancreas |
| cela1.2.L | elastase | X. laevis | Throughout NF stage 44 | foregut exocrine pancreas pancreas |
| ctse.L | cate, cathepsin E, ce1, ce2, ctse-a, ctse-b | X. laevis | Throughout NF stage 44 | foregut stomach |
| hhex.L | hex, tHex, XHex | X. laevis | Throughout NF stage 44 | foregut liver duodenum liver primordium |
Image source: Published
| Experiment + Assay | Source | Phenotypes and Disease | ||
|---|---|---|---|---|
| Xla Wt + neurog3-GR + DEX + NF44 (in situ hybridization) | Fig 2 b |
| ||
| Xla Wt + neurog3-GR + DEX + NF44 (in situ hybridization) | Fig 2 e |
| ||
| Xla Wt + neurog3-GR + DEX + NF44 (in situ hybridization) | Fig 2 h |
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