Highloights: ATP4 is required during gastrulation/neurulation for cilia-driven leftward flow to occur ► ATP4 acts on canonical and noncanonical Wnt signaling ► Wnt/β-catenin is necessary and sufficient for gastrula Foxj1 expression ► Leftward flow is the conserved mode of symmetry breakage in Xenopus
Image published in: Walentek P et al. (2012)
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