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Highloights: ATP4 is required during gastrulation/neurulation for cilia-driven leftward flow to occur ► ATP4 acts on canonical and noncanonical Wnt signaling ► Wnt/β-catenin is necessary and sufficient for gastrula Foxj1 expression ► Leftward flow is the conserved mode of symmetry breakage in Xenopus

Image published in: Walentek P et al. (2012)

Copyright © 2012. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.

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