Larger Image Figure 5. The First 32 Members of the Shortened Axis Phenotypic Class This class can be subdivided into six synphenotype groups, as indicated in Figure 3 and Table 4. Members of the first three synphenotype groups (involution defects, gastrula or neurula defects, and short axis surviving to tailbud) are shown at tailbud stage (stage 24�28), while the member of the second synphenotype group shown here (short axis surviving to tadpole) is shown at tadpole stage 35�41. Lines in this and subsequent figures demarcate the different synexpression groups. doi:10.1371/journal.pgen.0020193.g005 Image published in: Rana AA et al. (2006) Copyright © 2006. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Experiment + Assay Source Phenotypes and Disease Xtr Wt + acbd6 MO + NF10.5-11.5 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + acbd6 MO + NF24-28 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal axis elongation abnormal gastrulation absent head absent tail decreased length of anterior-posterior axis Xtr Wt + c19orf52 MO + NF10.5-11.5 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + c19orf52 MO + tailbud stage-tadpole stage (morphology) fig.5, Table 4 Anatomical Phenotype abnormal axis elongation abnormal head morphology abnormal tail bud morphology decreased length of anterior-posterior axis Xtr Wt + cers2 MO + NF10.5-11.5 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + cers2 MO + NF24-28 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal axis elongation absent head absent tail decreased length of anterior-posterior axis Xtr Wt + dctn2 MO + NF24-28 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal axis elongation abnormal head morphology abnormal tail morphology absent head absent tail decreased length of anterior-posterior axis Xtr Wt + dmd.1 MO + NF24-28 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal axis elongation abnormal head morphology abnormal tail morphology decreased length of anterior-posterior axis Xtr Wt + dmd.2 MO + NF10.5-11.5 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + dmd.2 MO + NF24-28 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal axis elongation abnormal gastrulation abnormal head morphology abnormal tail morphology decreased length of anterior-posterior axis Xtr Wt + dync2h1 MO + NF24-28 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal axis elongation abnormal embryo morphology abnormal gastrulation decreased length of anterior-posterior axis decreased size of the head Xtr Wt + ext1 MO + NF10.5-11.5 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + ext1 MO + tailbud stage-tadpole stage (morphology) fig.5, Table 4 Anatomical Phenotype wholly ventralized embryo Xtr Wt + ext1 MO + NF24-28 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal axis elongation abnormal head morphology abnormal tail morphology decreased length of anterior-posterior axis Xtr Wt + ext1 MO + tadpole stage (morphology) fig.5, Table 4 Anatomical Phenotype abnormal axis elongation abnormal bending of anterior-posterior axis abnormal development of embryo abnormal head morphology abnormal tail morphology decreased length of anterior-posterior axis Xtr Wt + fzd8 MO + NF10.5-11.5 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + fzd8 MO + NF10.5-11.5 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + fzd8 MO + tailbud stage (morphology) fig.5, Table 4 Anatomical Phenotype abnormal axis elongation abnormal head morphology abnormal incomplete closing of the neural tube abnormal neural tube closure abnormal tail morphology decreased length of anterior-posterior axis Xtr Wt + fzd8 MO + NF24-28 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal axis elongation abnormal embryo morphology abnormal gastrulation abnormal head morphology abnormal tail morphology decreased length of anterior-posterior axis decreased size of the head decreased size of the tail Xtr Wt + inhbb MO + NF10.5-11.5 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + inhbb MO + NF28 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal axis elongation abnormal head morphology abnormal tail bud morphology abnormal trunk morphology abnormally nodular trunk decreased length of anterior-posterior axis wholly ventralized embryo Xtr Wt + kdm2a MO + NF10.5-11.5 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + kdm2a MO + tadpole stage (morphology) fig.5, Table 4 Anatomical Phenotype abnormal axis elongation abnormal head morphology abnormal tail morphology decreased length of anterior-posterior axis Xtr Wt + loc100489386 MO + NF10.5-11.5 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + loc100489386 MO + NF24-28 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal axis elongation absent head absent tail decreased length of anterior-posterior axis Xtr Wt + mau2 MO + tailbud stage-tadpole stage (morphology) fig.5, Table 4 Anatomical Phenotype abnormal axis elongation abnormal head morphology abnormal tail morphology decreased length of anterior-posterior axis wholly ventralized embryo Xtr Wt + nipbl MO + NF24-28 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal axis elongation abnormal head morphology abnormal tail morphology abnormally ventralized embryo decreased length of anterior-posterior axis decreased size of the head Xtr Wt + nodal1 MO + NF10.5-11.5 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + nodal1 MO + NF24-28 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal axis elongation abnormal gastrulation absent head absent tail decreased length of anterior-posterior axis Xtr Wt + pard6b MO + NF10.5-11.5 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + pard6b MO + NF24-28 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal axis elongation absent head absent tail decreased length of anterior-posterior axis decreased size of the head Xtr Wt + rad51 MO + NF10.5-11.5 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + rad51 MO + NF24-28 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal axis elongation absent head absent tail decreased length of anterior-posterior axis decreased size of the head Xtr Wt + rb1 MO + NF10.5-11.5 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + rb1 MO + NF24-28 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal axis elongation absent head absent tail decreased length of anterior-posterior axis decreased size of the head Xtr Wt + smad4.1 MO + NF10.5-11.5 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + smad4.1 MO + NF24-28 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal axis elongation absent head absent tail decreased length of anterior-posterior axis Xtr Wt + smad7 MO + NF10.5-tadpole stage (morphology) fig.5, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + smad7 MO + NF28 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal axis elongation abnormal head morphology abnormal tail bud morphology decreased length of anterior-posterior axis wholly ventralized embryo Xtr Wt + spice1 MO + tailbud stage (morphology) fig.5, Table 4 Anatomical Phenotype abnormal axis elongation abnormal head morphology abnormal tail morphology decreased length of anterior-posterior axis wholly ventralized embryo Xtr Wt + tbx3 MO + NF10.5-11.5 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + tbx3 MO + NF24-28 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal axis elongation absent head absent tail decreased length of anterior-posterior axis decreased size of the head Xtr Wt + tmem70 MO + NF10.5-11.5 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + tmem70 MO + NF24-28 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal axis elongation absent head absent tail decreased length of anterior-posterior axis decreased size of the head Xtr Wt + ubn2 MO + NF10.5-11.5 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + ubn2 MO + NF24-28 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal axis elongation abnormally necrotic neural plate absent head absent tail decreased length of anterior-posterior axis Xtr Wt + ywhab MO + NF10.5-11.5 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + ywhab MO + NF24-28 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal axis elongation abnormal head morphology abnormal tail morphology decreased length of anterior-posterior axis Xtr Wt + ywhae MO + NF10.5-11.5 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + ywhae MO + NF24-28 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal axis elongation abnormal head morphology abnormal tail morphology decreased length of anterior-posterior axis decreased size of the head Xtr Wt + ywhah MO + NF10.5-11.5 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + ywhah MO + NF10.5-11.5 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + ywhah MO + NF24-28 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal axis elongation abnormal head morphology abnormal tail morphology decreased length of anterior-posterior axis decreased size of the head Xtr Wt + ywhah MO + NF24-28 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal axis elongation abnormal head morphology abnormal tail morphology absent head decreased length of anterior-posterior axis decreased size of the head Xtr Wt + ywhaq MO + NF10.5-11.5 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal gastrulation abnormally delayed closure of blastopore Xtr Wt + ywhaq MO + NF24-28 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal axis elongation abnormal head morphology abnormal tail morphology abnormal trunk morphology absent head decreased length of anterior-posterior axis Xtr Wt + zfp160 MO + NF10.5-11.5 (morphology) fig.5, Table 4 Anatomical Phenotype abnormally delayed closure of blastopore Xtr Wt + zfp160 MO + NF24-28 (morphology) fig.5, Table 4 Anatomical Phenotype abnormal axis elongation abnormal head morphology abnormal tail morphology decreased length of anterior-posterior axis decreased size of the head Permanent Image Page Printer Friendly View XB-IMG-82960