Fig. 7. Effect of XPtc1 Loop2 and cyclopamine treatment on otic specification. (A-E) Embryos were injected with XPtc1 Loop2 mRNA (750 pg) into one of two cells, fixed at stage 36, and stained for Xdll-3 expression. Embryos injected with XPtc1 Loop2, a dominant-negative form of XPtc1, exhibit ectopic vesicular structures expressing Xdll-3 (31%, n 36) (indicated by arrows) and enlarged otic vesicles (E). (F) Normal-sized otic vesicle in control embryo treated with 0.38% ethanol (100%, n 10). (G) Enlarged otic vesicle developed upon treatment with 20 M cyclopamine (50%, n 8). Con, control; cyc, cyclopamine; is, injected side; nis, noninjected side.
Image published in: Koebernick K et al. (2003)
Copyright © 2003. Image reproduced with permission of the Publisher, Elsevier B. V.
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| dlx5.L | dll3, X-dll3 | X. laevis | Throughout NF stage 35 and 36 | otic vesicle brain forebrain pharyngeal arch mandibular arch hyoid arch |
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