Fig. 5. The level of retinoid signalling in the embryo does not affect the lateral extent of the neurectoderm. (A–C). sox-2 expression in embryos unilaterally injected with: (A) RAR/RXR, (B) RAR/RXR with the addition of RA and (C) RARdn mRNA. The injected side is marked by a red dot, the midline by a horizontal bar and the lateral extent of the neurectoderm by vertical bars. Although the morphology of the neural plate, particularly in the anterior neurectoderm is altered in embryos treated with RA (B), the lateral extent of sox-2 expression is unaltered compared to the control sides in each of the manipulations. (D,E) The expression of sox-2 in normal (D) and citral-treated (E) neurula stage embryos. Although the citral treated embryos show morphological changes compared to the normal controls, the expression of sox-2 was unaffected. This suggests that although treatment with citral inhibits the primary neurogenesis it is not doing so by eliminating the formation of the neurectoderm.
Image published in: Sharpe C and Goldstone K (2000)
Copyright © 2000. Image reproduced with permission of the Publisher, Elsevier B. V.
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